Nattokinase Cardiovascular Benefits

By Tucson Functional Medicine on December 20, 2021 0 Comments

Nattokinase is an enzyme extracted from a popular Japanese food called natto. Natto is boiled soybeans that have been fermented with a bacterium called Bacillus natto.

Nattokinase has been found to keep blood optimally flowing and promote cardiovascular health.

According to the research on this powerful enzyme, it can lower blood pressure, help reduce the risk of atherosclerosis, help lower blood fats, support optimal blood flow with its anticoagulant properties, and even be neuroprotective.

Nattokinase has the unique ability to dissolve fibrin, a protein that helps our body form clots. As a result, as we age, we can experience increased blood viscosity or thickness. Blood that is too ‘thick’ is more prone to clotting and doesn’t flow as easily through the blood vessels. This can increase blood pressure as the heart has to pump harder to circulate the same blood. Nattokinase helps decrease blood viscosity, or thick, sludgy blood, and supports healthy blood flow.

Nattokinase has been associated with decreasing systolic and diastolic blood pressure.

In 2008 a randomized, double-blind, placebo-controlled trial on nattokinase looked at 86 individuals with high blood pressure. They received nattokinase or a placebo for eight weeks. Seventy-three subjects completed the study, and those taking nattokinase significantly reduced blood pressure.

Nattokinase has been found to help with atherosclerosis (hardening the arteries).

In a 26-week study, 82 randomized volunteers took either 300 mg of nattokinase daily or 20 mg every day of the anti-cholesterol medication simvastatin.

In people taking nattokinase, arterial wall thickness and the size of arterial plaques significantly decreased. For example, in the nattokinase group, plaque size decreased by 36.6% compared with only an 11.5% reduction in the simvastatin group.

An added benefit included that volunteers taking nattokinase showed significant reductions in total cholesterol, low-density lipoprotein cholesterol (bad cholesterol), and triglyceride. Unfortunately, at the same time, their high-density lipoprotein cholesterol (good cholesterol) increased. 

Take Away

Based on my review of the medical literature, adding nattokinase to a cardiovascular protocol has good value and may be life-saving.

It is suggested that nattokinase could be a good health functional food to improve blood flow.


People who take blood thinners, including warfarin, need to know that nattokinase may promote bleeding and easy bruising and should consult their doctor before taking it.



Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.

%d bloggers like this: