Low Oxalates Foods May Help Reduce Auto-Immune Disease Risk, Autism and Fibromyalgia

By Tucson Functional Medicine on May 17, 2022 0 Comments

Oxalate (or oxalic acid) is a compound found in various plant-based foods. Under a microscope, oxalates are jagged in structure and look somewhat crystalline.

During metabolism, oxalic acid combines with other minerals like calcium, sodium, magnesium, and potassium to form compounds like calcium oxalate and sodium oxalate in the kidneys. This, in turn, may be responsible for mineral deficiencies.

One of the most common issues with increased oxalates in the urine (hyperoxaluria) is the formation of kidney stones. However, if the body struggles to eliminate oxalate, it can accumulate as crystals anywhere in the body. Commonly it gets in the blood, then the eyes, bones, skin, muscles, blood vessels, heart, and other organs.

High oxalates have also been linked with autism and inflammatory bowel disease. It can also be an underlying issue in those with ongoing gut problems or irritable bowel syndrome.

Tissue destruction, fibromyalgia, and autoimmune diseases such as rheumatoid arthritis and lupus are all issues that can be related to oxalates because oxalate in tissues triggers the inflammasome reactions of the body’s innate immune system.

As a side note, the thyroid will also suffer as oxalates can bind to T3 and disturb thyroid function.

The following list of vegetables should be helpful in identifying foods high in oxalates


Low Oxalates Foods May Help Reduce Auto-Immune Disease Risk, Autism and Fibromyalgia

As you can see from the list above, your favorite spinach (> 900 mg of oxalates) green smoothie may be contributing to a host of health issues!

Low oxalate diets involve eating less food that’s high in oxalates. Foods high in oxalates include certain fruits, vegetables, nuts, grains, and legumes.

On a low oxalate diet, you should limit your oxalate to 40 to 50 mg each day.


A low oxalate diet may be the solution, whether for kidney stone prevention or to address other possible chronic health conditions.

On a low oxalate diet, you may notice a decreased risk of kidney stones, improved mineral absorption, diminished joint and muscle pain, improvement in fibromyalgia, autism symptoms, and improvement of autoimmune symptoms.


The damaging effects of oxalates


Oxalate, inflammasome, kidney disease

How to eat a low oxalate diet/

Oxalates control in autism therapy

Pubmed – Pathogenic role in autism

Pathogenic role in autism

Increased cardiovascular disease

Arterial plaque contains oxalate/

Lowering urinary oxalate excretion

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